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Co-administration in research models would not produce additive receptor-level effects through distinct binding sites, a consideration that distinguishes this pair from, for example, ipamorelin combined with a GHRH receptor agonist such as sermorelin or CJC-1295

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However, hormonal effects such as increased testosterone and follicle-stimulating hormone levels have been observed, thus indicating that individuals with hormone-sensitive conditions may experience adverse effects when taking Shilajit